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蛇葡萄素和運動模擬劑在慢性疾病中的生物功能及機制 版權信息
- ISBN：9787568043007
- 條形碼：9787568043007 ; 978-7-5680-4300-7
- 裝幀：平裝-膠訂
- 冊數：暫無
- 重量：暫無
- 所屬分類：>>
蛇葡萄素和運動模擬劑在慢性疾病中的生物功能及機制 本書特色
蛇葡萄素（Ampelopsin）又名雙氫楊梅素（dihydromyricetin，DMY）是藤茶中一種重要的黃酮類物質。研究表明，Ampelopsin具有廣泛的生物學功能：抗炎、抗氧化、抗腫瘤、保肝、改善運動疲勞等。
本書首從Ampelopsin的結構入手，然后分章節來探討Ampelopsin的抗炎、抗氧化、抗腫瘤、保肝、神經保護、改善運動疲勞及衰老性肌萎縮的作用；闡明Ampelopsin發揮上述作用的信號分子或者靶標；Ampelopsin發展成為功能性食品的前景。
蛇葡萄素和運動模擬劑在慢性疾病中的生物功能及機制 內容簡介
蛇葡萄素（Ampelopsin）又名雙氫楊梅素（dihydromyricetin，DMY）是藤茶中一種重要的黃酮類物質。研究表明，Ampelopsin具有廣泛的生物學功能：抗炎、抗氧化、抗腫瘤、保肝、改善運動疲勞等。本書首從Ampelopsin的結構入手，然后分章節來探討Ampelopsin的抗炎、抗氧化、抗腫瘤、保肝、神經保護、改善運動疲勞及衰老性肌萎縮的作用；闡明Ampelopsin發揮上述作用的信號分子或者靶標；Ampelopsin發展成為功能性食品的前景。
蛇葡萄素和運動模擬劑在慢性疾病中的生物功能及機制 目錄
The Biological Function and Molecular Mechanism of Ampelopsin and Exercise Mimetics in Chronic DiseasesContentsChapter 1Pharmacological potential of ampelopsin in Rattan tea1
Chapter 2Ampelopsin reduces endotoxic inflammation via repressing ROSmediated
activation of PI3K/Akt/NFκB signaling pathways8
Chapter 3Natural products for cancer prevention associated with Nrf2ARE pathway23
Chapter 4Antitumor effect31
4.1Potential molecular targets of ampelopsin in prevention and treatment of
cancers31
4.2Nutraceutical or pharmacological potential of Moringa oleifera Lam.39
4.3Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through
extrinsic and intrinsic pathways：involvement of p38 and ERK48
Chapter 5Neuroprotective effect59
5.1Ampelopsin inhibits H2O2induced apoptosis by ERK and Akt signaling
pathways and upregulation of heme oxygenase159
5.2Ampelopsin attenuates 6OHDAinduced neurotoxicity by regulating
GSK3β/NRF2/ARE signaling67
Chapter 6Autophagy and brain aging77
6.1Autophagy as the modulator of neuronal homeostasis and neurodegenerative disorders77
6.2Resveratrol as a natural autophagy regulator for prevention and treatment of Alzheimer’s disease80
6.3Ampelopsin attenuates brain aging of Dgalinduced rats through miR34amediated SIRT1/mTOR signaling pathway89
6.4Swimming attenuates Dgalactoseinduced brain aging via suppressing miR34amediated autophagy impairment and abnormal mitochondrial dynamics101
6.5Voluntary wheel running exercise suppresses brain aging of rats through activating miR130amediated autophagy112
Chapter 7Sarcopenia123
7.1Research progress of sarcopenia123
7.2MicroRNAregulated proinflammatory cytokines in sarcopenia127
7.3Ampelopsin attenuates Dgalinduced oxidative stressrelated skeletal muscle atrophy through activating AMPK/SIRT1/PGC1α signaling cascade135
7.4Role and regulation of autophagy in mass maintenance of skeletal muscle147
Acknowledgement155
References156
Chapter 2Ampelopsin reduces endotoxic inflammation via repressing ROSmediated
activation of PI3K/Akt/NFκB signaling pathways8
Chapter 3Natural products for cancer prevention associated with Nrf2ARE pathway23
Chapter 4Antitumor effect31
4.1Potential molecular targets of ampelopsin in prevention and treatment of
cancers31
4.2Nutraceutical or pharmacological potential of Moringa oleifera Lam.39
4.3Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through
extrinsic and intrinsic pathways：involvement of p38 and ERK48
Chapter 5Neuroprotective effect59
5.1Ampelopsin inhibits H2O2induced apoptosis by ERK and Akt signaling
pathways and upregulation of heme oxygenase159
5.2Ampelopsin attenuates 6OHDAinduced neurotoxicity by regulating
GSK3β/NRF2/ARE signaling67
Chapter 6Autophagy and brain aging77
6.1Autophagy as the modulator of neuronal homeostasis and neurodegenerative disorders77
6.2Resveratrol as a natural autophagy regulator for prevention and treatment of Alzheimer’s disease80
6.3Ampelopsin attenuates brain aging of Dgalinduced rats through miR34amediated SIRT1/mTOR signaling pathway89
6.4Swimming attenuates Dgalactoseinduced brain aging via suppressing miR34amediated autophagy impairment and abnormal mitochondrial dynamics101
6.5Voluntary wheel running exercise suppresses brain aging of rats through activating miR130amediated autophagy112
Chapter 7Sarcopenia123
7.1Research progress of sarcopenia123
7.2MicroRNAregulated proinflammatory cytokines in sarcopenia127
7.3Ampelopsin attenuates Dgalinduced oxidative stressrelated skeletal muscle atrophy through activating AMPK/SIRT1/PGC1α signaling cascade135
7.4Role and regulation of autophagy in mass maintenance of skeletal muscle147
Acknowledgement155
References156
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蛇葡萄素和運動模擬劑在慢性疾病中的生物功能及機制 作者簡介
寇現娟，女，副教授。健康科學學院運動醫學教研室教師。鄭州大學醫學院生物化學與分子生物學專業碩士，華中科技大學同濟醫學院生物化學與分子生物學專業博士。
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