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病理生理學(xué)-(留學(xué)生與雙語教學(xué)用)-(英文原版改編版) 版權(quán)信息
- ISBN：9787302463382
- 條形碼：9787302463382 ; 978-7-302-46338-2
- 裝幀：一般膠版紙
- 冊(cè)數(shù)：暫無
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病理生理學(xué)-(留學(xué)生與雙語教學(xué)用)-(英文原版改編版) 本書特色
《病理生理學(xué)》將中文教材和英文圖書《 Pathophysiology 》進(jìn)行結(jié)合調(diào)整，章節(jié)內(nèi)容、順序基本與中文教材一致，系統(tǒng)完善地介紹了病理生理學(xué)的基本理論，適用于留學(xué)生本科教學(xué)。在內(nèi)容上除沿用了部分病理生理學(xué)傳統(tǒng)內(nèi)容外，還增加了一些*前沿的基礎(chǔ)醫(yī)學(xué)研究，并引用很多新的臨床實(shí)例，與臨床醫(yī)學(xué)的銜接也更加緊密，使病理生理學(xué)真正成為溝通基礎(chǔ)醫(yī)學(xué)與臨床醫(yī)學(xué)的橋梁。 本書將《 病理生理學(xué) 》中文教材和英文圖書《 Pathophysiology 》進(jìn)行結(jié)合調(diào)整，章節(jié)內(nèi)容、順序基本與中文教材一致，系統(tǒng)完善地介紹了病理生理學(xué)的基本理論，適用于留學(xué)生本科教學(xué)
病理生理學(xué)-(留學(xué)生與雙語教學(xué)用)-(英文原版改編版) 內(nèi)容簡(jiǎn)介
《病理生理學(xué)》是一門研究疾病發(fā)生、發(fā)展和轉(zhuǎn)歸規(guī)律的基礎(chǔ)醫(yī)學(xué)學(xué)科。它既是一門醫(yī)學(xué)基礎(chǔ)學(xué)科，也是一門醫(yī)學(xué)交叉學(xué)科。由于它是運(yùn)用生理學(xué)、生物化學(xué)、微生物學(xué)、免疫學(xué)等基礎(chǔ)學(xué)科的相關(guān)知識(shí)解釋疾病發(fā)生機(jī)制，所以被稱為溝通基礎(chǔ)醫(yī)學(xué)與臨床醫(yī)學(xué)的橋梁。
病理生理學(xué)-(留學(xué)生與雙語教學(xué)用)-(英文原版改編版) 目錄
Contents
目.錄
Chapter 1 Altered Cellular and Tissue Biology…………………………………………………………………………… 1 Cellular Injury ………………………………………………………………………………………………………… 1 Cellular Death ……………………………………………………………………………………………………… 10 agIng anD altereD Cellular anD tIssue BIology …………………………………………………… 11 somatIC Death ……………………………………………………………………………………………………… 12
Chapter 2 Fluids and Electrolytes, Acids and Bases ………………………………………………………………… 13 DIstrIButIon of BoDy fluIDs anD eleCtrolytes ………………………………………………………… 13 alteratIons In Water movement …………………………………………………………………………… 15 soDIum, ChlorIDe, anD Water BalanCe …………………………………………………………………… 16 alteratIons In soDIum, ChlorIDe, anD Water BalanCe …………………………………………… 18 alteratIons In PotassIum anD other eleCtrolytes ………………………………………………… 21 aCID-Base BalanCe ………………………………………………………………………………………………… 27 aCID-Base ImBalanCes……………………………………………………………………………………………… 30
Chapter 3 Stress and Disease ……………………………………………………………………………………………… 33 hIstorICal BaCkgrounD anD general ConCePts ……………………………………………………… 33 the stress resPonse ………………………………………………………………………………………………… 37 stress, PersonalIty, CoPIng, anD Illness ………………………………………………………………… 46
Chapter 4 Biology of Cancer ……………………………………………………………………………………………… 50 CanCer termInology anD CharaCterIstICs……………………………………………………………… 50 the BIology of CanCer Cells …………………………………………………………………………………… 51 ClInICal manIfestatIons of CanCer ………………………………………………………………………… 61 DIagnosIs, CharaCterIzatIon, anD treatment of CanCer………………………………………… 63
Chapter 5 Cancer Epidemiology ………………………………………………………………………………………… 67 genetICs, ePIgenetICs, anD tIssue …………………………………………………………………………… 68 In utero anD early lIfe ConDItIons ………………………………………………………………………… 68 envIronmental-lIfestyle faCtors ………………………………………………………………………… 68
Chapter 6 Pain, Temperature and Sleep ………………………………………………………………………………… 80 PaIn ……………………………………………………………………………………………………………………… 80 temPerature regulatIon………………………………………………………………………………………… 86 sleeP ……………………………………………………………………………………………………………………… 90
Chapter 7 Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function ……………… 92
alteratIons In CognItIve systems …………………………………………………………………………… 92
alteratIons In CereBral hemoDynamICs ………………………………………………………………… 106
alteratIons In neuromotor funCtIon …………………………………………………………………… 109
Chapter 8 Disorders of the Central and Peripheral Nervous Systems and Neuromuscular Junction ……… 113 Central nervous system DIsorDers ………………………………………………………………………… 113 PerIPheral nervous system anD neuromusCular junCtIon DIsorDers ……………………… 131
Chapter 9 Alterations of Hormonal Regulation ……………………………………………………………………… 133 meChanIsms of hormonal alteratIons…………………………………………………………………… 133 alteratIons of the hyPothalamIC-PItuItary system ……………………………………………… 134 alteratIons of thyroID funCtIon …………………………………………………………………………… 139 alteratIons of ParathyroID funCtIon …………………………………………………………………… 143 DysfunCtIon of the enDoCrIne PanCreas: DIaBetes mellItus …………………………………… 144 alteratIons of aDrenal funCtIon ………………………………………………………………………… 154 tumors of the aDrenal meDulla …………………………………………………………………………… 157
Chapter 10 Structure and Function of the Hematologic System …………………………………………………… 159 ComPonents of the hematologIC system ………………………………………………………………… 159 meChanIsms of hemostasIs ……………………………………………………………………………………… 165 antICoagulant system …………………………………………………………………………………………… 169
Chapter 11 Alterations of Hematologic Function……………………………………………………………………… 171 alteratIons of erythroCyte funCtIon …………………………………………………………………… 171 alteratIons of leukoCyte funCtIon ……………………………………………………………………… 179 hemorrhagIC DIsorDers anD alteratIons of Platelets anD CoagulatIon ……………… 185
Chapter 12 Regulation of Cardiovascular Function ………………………………………………………………… 194 the CIrCulatory system ………………………………………………………………………………………… 194 the systemIC CIrCulatIon ……………………………………………………………………………………… 197
Chapter 13 Alterations of Cardiovascular Function ………………………………………………………………… 205 DIseases of the arterIes ………………………………………………………………………………………… 205 manIfestatIons of heart DIsease …………………………………………………………………………… 225 shoCk …………………………………………………………………………………………………………………… 230
Chapter 14 Function of the Pulmonary System ……………………………………………………………………… 241
funCtIon of the Pulmonary system ………………………………………………………………………… 241
Chapter 15 Alterations of Pulmonary Function ……………………………………………………………………… 251 ClInICal manIfestatIons of Pulmonary alteratIons ……………………………………………… 251 Pulmonary DIsorDers …………………………………………………………………………………………… 258
Chapter 16 Function of the Renal and Urologic Systems …………………………………………………………… 280 regulatIon of renal BlooD floW …………………………………………………………………………… 280 kIDney funCtIon …………………………………………………………………………………………………… 281 tests of renal funCtIon ………………………………………………………………………………………… 285
Chapter 17 Alterations of Renal and Urinary Tract Function ……………………………………………………… 288 urInary traCt oBstruCtIon …………………………………………………………………………………… 288 urInary traCt InfeCtIon ………………………………………………………………………………………… 295 glomerular DIsorDers …………………………………………………………………………………………… 298 aCute kIDney Injury ……………………………………………………………………………………………… 301 ChronIC kIDney DIsease…………………………………………………………………………………………… 305
Chapter 18 Alterations of the Female Reproductive System ……………………………………………………… 311 Chapter 19 Alterations of Digestive Function ………………………………………………………………………… 331
DIsorDers of the gastroIntestInal traCt ……………………………………………………………… 331 DIsorDers of the aCCessory organs of DIgestIon …………………………………………………… 347 CanCer of the DIgestIve system ……………………………………………………………………………… 358
Chapter 20 Alterations of Musculoskeletal Function ………………………………………………………………… 362 musCuloskeletal InjurIes ……………………………………………………………………………………… 362 DIsorDers of Bones ………………………………………………………………………………………………… 371 DIsorDers of joInts ………………………………………………………………………………………………… 380 DIsorDers of skeletal musCle ………………………………………………………………………………… 394 musCuloskeletal tumors ……………………………………………………………………………………… 402
目.錄
Chapter 1 Altered Cellular and Tissue Biology…………………………………………………………………………… 1 Cellular Injury ………………………………………………………………………………………………………… 1 Cellular Death ……………………………………………………………………………………………………… 10 agIng anD altereD Cellular anD tIssue BIology …………………………………………………… 11 somatIC Death ……………………………………………………………………………………………………… 12
Chapter 2 Fluids and Electrolytes, Acids and Bases ………………………………………………………………… 13 DIstrIButIon of BoDy fluIDs anD eleCtrolytes ………………………………………………………… 13 alteratIons In Water movement …………………………………………………………………………… 15 soDIum, ChlorIDe, anD Water BalanCe …………………………………………………………………… 16 alteratIons In soDIum, ChlorIDe, anD Water BalanCe …………………………………………… 18 alteratIons In PotassIum anD other eleCtrolytes ………………………………………………… 21 aCID-Base BalanCe ………………………………………………………………………………………………… 27 aCID-Base ImBalanCes……………………………………………………………………………………………… 30
Chapter 3 Stress and Disease ……………………………………………………………………………………………… 33 hIstorICal BaCkgrounD anD general ConCePts ……………………………………………………… 33 the stress resPonse ………………………………………………………………………………………………… 37 stress, PersonalIty, CoPIng, anD Illness ………………………………………………………………… 46
Chapter 4 Biology of Cancer ……………………………………………………………………………………………… 50 CanCer termInology anD CharaCterIstICs……………………………………………………………… 50 the BIology of CanCer Cells …………………………………………………………………………………… 51 ClInICal manIfestatIons of CanCer ………………………………………………………………………… 61 DIagnosIs, CharaCterIzatIon, anD treatment of CanCer………………………………………… 63
Chapter 5 Cancer Epidemiology ………………………………………………………………………………………… 67 genetICs, ePIgenetICs, anD tIssue …………………………………………………………………………… 68 In utero anD early lIfe ConDItIons ………………………………………………………………………… 68 envIronmental-lIfestyle faCtors ………………………………………………………………………… 68
Chapter 6 Pain, Temperature and Sleep ………………………………………………………………………………… 80 PaIn ……………………………………………………………………………………………………………………… 80 temPerature regulatIon………………………………………………………………………………………… 86 sleeP ……………………………………………………………………………………………………………………… 90
Chapter 7 Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function ……………… 92
alteratIons In CognItIve systems …………………………………………………………………………… 92
alteratIons In CereBral hemoDynamICs ………………………………………………………………… 106
alteratIons In neuromotor funCtIon …………………………………………………………………… 109
Chapter 8 Disorders of the Central and Peripheral Nervous Systems and Neuromuscular Junction ……… 113 Central nervous system DIsorDers ………………………………………………………………………… 113 PerIPheral nervous system anD neuromusCular junCtIon DIsorDers ……………………… 131
Chapter 9 Alterations of Hormonal Regulation ……………………………………………………………………… 133 meChanIsms of hormonal alteratIons…………………………………………………………………… 133 alteratIons of the hyPothalamIC-PItuItary system ……………………………………………… 134 alteratIons of thyroID funCtIon …………………………………………………………………………… 139 alteratIons of ParathyroID funCtIon …………………………………………………………………… 143 DysfunCtIon of the enDoCrIne PanCreas: DIaBetes mellItus …………………………………… 144 alteratIons of aDrenal funCtIon ………………………………………………………………………… 154 tumors of the aDrenal meDulla …………………………………………………………………………… 157
Chapter 10 Structure and Function of the Hematologic System …………………………………………………… 159 ComPonents of the hematologIC system ………………………………………………………………… 159 meChanIsms of hemostasIs ……………………………………………………………………………………… 165 antICoagulant system …………………………………………………………………………………………… 169
Chapter 11 Alterations of Hematologic Function……………………………………………………………………… 171 alteratIons of erythroCyte funCtIon …………………………………………………………………… 171 alteratIons of leukoCyte funCtIon ……………………………………………………………………… 179 hemorrhagIC DIsorDers anD alteratIons of Platelets anD CoagulatIon ……………… 185
Chapter 12 Regulation of Cardiovascular Function ………………………………………………………………… 194 the CIrCulatory system ………………………………………………………………………………………… 194 the systemIC CIrCulatIon ……………………………………………………………………………………… 197
Chapter 13 Alterations of Cardiovascular Function ………………………………………………………………… 205 DIseases of the arterIes ………………………………………………………………………………………… 205 manIfestatIons of heart DIsease …………………………………………………………………………… 225 shoCk …………………………………………………………………………………………………………………… 230
Chapter 14 Function of the Pulmonary System ……………………………………………………………………… 241
funCtIon of the Pulmonary system ………………………………………………………………………… 241
Chapter 15 Alterations of Pulmonary Function ……………………………………………………………………… 251 ClInICal manIfestatIons of Pulmonary alteratIons ……………………………………………… 251 Pulmonary DIsorDers …………………………………………………………………………………………… 258
Chapter 16 Function of the Renal and Urologic Systems …………………………………………………………… 280 regulatIon of renal BlooD floW …………………………………………………………………………… 280 kIDney funCtIon …………………………………………………………………………………………………… 281 tests of renal funCtIon ………………………………………………………………………………………… 285
Chapter 17 Alterations of Renal and Urinary Tract Function ……………………………………………………… 288 urInary traCt oBstruCtIon …………………………………………………………………………………… 288 urInary traCt InfeCtIon ………………………………………………………………………………………… 295 glomerular DIsorDers …………………………………………………………………………………………… 298 aCute kIDney Injury ……………………………………………………………………………………………… 301 ChronIC kIDney DIsease…………………………………………………………………………………………… 305
Chapter 18 Alterations of the Female Reproductive System ……………………………………………………… 311 Chapter 19 Alterations of Digestive Function ………………………………………………………………………… 331
DIsorDers of the gastroIntestInal traCt ……………………………………………………………… 331 DIsorDers of the aCCessory organs of DIgestIon …………………………………………………… 347 CanCer of the DIgestIve system ……………………………………………………………………………… 358
Chapter 20 Alterations of Musculoskeletal Function ………………………………………………………………… 362 musCuloskeletal InjurIes ……………………………………………………………………………………… 362 DIsorDers of Bones ………………………………………………………………………………………………… 371 DIsorDers of joInts ………………………………………………………………………………………………… 380 DIsorDers of skeletal musCle ………………………………………………………………………………… 394 musCuloskeletal tumors ……………………………………………………………………………………… 402
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病理生理學(xué)-(留學(xué)生與雙語教學(xué)用)-(英文原版改編版) 節(jié)選
Chapter 1 Altered Cellular and Tissue Biology The majority of diseases are caused by many factors acting together (i.e., multifactorial) or interacting with a genetically susceptible person. Injury to cells and their surrounding environment, called the extracellular matrix, leads to tissue and organ injury. Although the normal cell is restricted by a narrow range of structure and functions, including metabolism and specialization, it can adapt to physiologic demands or stress to maintain a steady state called homeostasis. Adaptation is a reversible, structural, or functional response both to normal or physiologic conditions and to adverse or pathologic conditions. For example, the uterus adapts to pregnancy—a normal physiologic state—by enlarging. Enlargement occurs because of an increase in the size and number of uterine cells. In an adverse condition, such as high blood pressure, myocardial cells are stimulated to enlarge by the increased work of pumping. Like most of the body’s adaptive mechanisms, however, cellular adaptations to adverse conditions are usually only temporarily successful. Severe or long-term stressors overwhelm adaptive processes and cellular injury or death ensues. Altered cellular and tissue biology can result from adaptation, injury, neoplasia, accumulations, aging, or death. Knowledge of the structural and functional reactions of cells and tissues to injurious agents, including genetic defects, is vital to understanding disease processes. Cellular injury can be caused by any factor that disrupts cellular structures or deprives the cell of oxygen and nutrients required for survival. Injury may be reversible (sublethal) or irreversible (lethal) and is classified broadly as chemical, hypoxic (lack of sufficient oxygen), free radical, intentional, unintentional, immunologic, infection, and inflammatory. Cellular injuries from various causes have different clinical and pathophysiologic manifestations. Stresses from metabolic derangements may be associated with intracellular accumulations and include carbohydrates, proteins, and lipids. Sites of cellular death can cause accumulations of calcium resulting in pathologic calcification. Cellular death is confirmed by structural changes seen when cells are stained and examined under a microscope. The two main types of cell death include necrosis and apoptosis and nutrient deprivation can initiate autophagy that results in cell death. All of these pathways of cellular death are discussed later in this chapter. Cellular aging causes structural and functional changes that eventually may lead to cellular death or a decreased capacity to recover from injury. Mechanisms explaining how and why cells age are not known, and distinguishing between pathologic changes and physiologic changes that occur with aging is often difficult. Aging clearly causes alterations in cellular structure and function, yet senescence, growing old, is both inevitable and normal. Cellular Injury Injury to cells and to the extracellular matrix (ECM) leads to injury of tissues and organs, ultimately determining the structural patterns of disease. Loss of function is derived from cell and ECM injury and cell death. Cellular injury occurs if the cell is unable to maintain homeostasis—a normal or adaptive steady state—in the face of injurious stimuli or stress. Injured cells may recover (reversible injury) or die (irreversible injury). Injurious stimuli include chemical agents, lack of sufficient oxygen (hypoxia), free radicals, infectious agents, physical and mechanical factors, immunologic reactions, genetic factors, and nutritional imbalances. Types of injuries and their responses are summarized in Table 1-1 and Figure 1-1. The extent of cellular injury depends on the type, state (including level of cell differentiation and increased susceptibility to fully differentiated cells), and adaptive processes of the cell, as well as the type, severity, and duration of the injurious stimulus. Two individuals exposed to an identical stimulus may incur varying degrees of cellular injury. Modifying factors, such as nutritional status, can profoundly influence the extent of injury. The precise “point of no return” that leads to cellular death is a biochemical puzzle, but once changes to the nucleus occur and cell membranes are disrupted, the cell moves to irreversible injury and death. FIGURE 1-1 Stages of Cellular Adaptation, Injury, and Death. The normal cell responds to physiologic and pathologic stresses by adapting (atrophy, hypertrophy, hyperplasia, metaplasia). Cell injury occurs if the adaptive responses are exceeded or compromised by injurious agents, stress, and mutations. The injury is reversible if it is mild or transient, but if the stimulus persists the cell suffers irreversible injury and eventually death. TABLE 1-1 Types of Progressive Cell Injury and Responses Type Responses Adaptation Atrophy, hypertrophy, hyperplasia, metaplasia Active cell injury Immediate response of “entire” cell Reversible Loss of ATP, cellular swelling, detachment of ribosomes, autophagy of lysosomes Irreversible “Point of no return” structurally when severe vacuolization of mitochondria occurs and Ca++ moves into cell Necrosis Common type of cell death with severe cell swelling and breakdown of organelles Apoptosis, or Cellular self-destruction for elimination programmed of unwanted cell populations cell death Autophagy Eating of self, cytoplasmic vesicles engulf cytoplasm and organelles, recycling factory Chronic cell injury Persistent stimuli response may involve (subcellular only specific organelles or cytoskeleton alterations) (e.g., phagocytosis of bacteria) Accumulations or Water, pigments, lipids, glycogen, infiltrations proteins ……
病理生理學(xué)-(留學(xué)生與雙語教學(xué)用)-(英文原版改編版) 作者簡(jiǎn)介
徐哲龍教授于1998年獲得日本山形大學(xué)醫(yī)學(xué)博士學(xué)位，1999年進(jìn)入美國南阿拉巴馬大學(xué)進(jìn)行博士后研究，2001年以研究員身份就職于美國北卡羅來納大學(xué)麻醉系，2006年升至助理教授，2011年被聘為“天津市特聘教授”及“‘211工程’特聘教授”，2012年被任命為“天津醫(yī)科大學(xué)基礎(chǔ)醫(yī)學(xué)院生理學(xué)與病理生理學(xué)系系主任”。主要研究方向?yàn)槿毖呐K的保護(hù)機(jī)制，先后主持多項(xiàng)美國國立衛(wèi)生研究院（NIH）基金課題及國家自然基金課題，以一作者或一通訊作者發(fā)表SCI論文30余篇，被引用700多次，并在多個(gè)高水平雜志擔(dān)任編委，如： Basic Research in Cardiology (IF 7.4)及Managing Editor for Frontiers in Bioscience (IF 3.7)。
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