Contributors. . vii Preface. . xi SECTION I INTRODUCTION TO CARDIOVASCULAR DISORDERS 1 Basic Biology of the Cardiovascular System. . .. 2 Joseph Loscalzo, Peter Libby, Jonathan A. Epstein 2 Epidemiology of Cardiovascular Disease. . 18 Thomas A. Gaziano, J. Michael Gaziano 3 Approach to the Patient with Possible Cardiovascular Disease. 25 Joseph Loscalzo SECTION II DIAGNOSIS OF CARDIOVASCULAR DISORDERS 4 Chest Discomfort. 32 David A. Morrow 5 Dyspnea. 45 Richard M. Schwartzstein 6 Hypoxia and Cyanosis. 52 Joseph Loscalzo 7 Edema. 57 Eugene Braunwald, Joseph Loscalzo 8 Palpitations. 63 Joseph Loscalzo 9 Physical Examination of the Cardiovascular System. 65 Patrick T. O’Gara, Joseph Loscalzo 10 Approach to the Patient with a Heart Murmur. . .. 79 Patrick T. O’Gara, Joseph Loscalzo 11 Electrocardiography. 92 Ary L. Goldberger 12 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography Imaging. 105 Marcelo F. Di Carli, Raymond Y. Kwong, Scott D. Solomon 13 Diagnostic Cardiac Catheterization and Coronary Angiography. . . . . . . . . . . . . . . . . .143 Jane A. Leopold, David P. Faxon SECTION III HEART RHYTHM DISTURBANCES 14 Principles of Electrophysiology. 154 David D. Spragg, Gordon F. Tomaselli 15 The Bradyarrhythmias: Disorders of the Sinoatrial Node. . . . . . . . . . . . . . . . . . . . . . .164 David D. Spragg, Gordon F. Tomaselli 16 The Bradyarrhythmias: Disorders of the Atrioventricular Node. 171 David D. Spragg, Gordon F. Tomaselli 17 Supraventricular Tachyarrhythmias. 179 Gregory F. Michaud, William G. Stevenson 18 Ventricular Arrhythmias. 197 Roy M. John, William G. Stevenson SECTION IV DISORDERS OF THE HEART 19 Heart Failure: Pathophysiology and Diagnosis. 214 Douglas L. Mann, Murali Chakinala 20 Heart Failure: Management. . . . . . . . . . . . . . . . . .224 Mandeep R. Mehra 21 Cardiac Transplantation and Prolonged Assisted Circulation. 239 Sharon A. Hunt, Hari R. Mallidi 22 Congenital Heart Disease in the Adult. 245 Jamil A. Aboulhosn, John S. Child 23 Aortic Valve Disease. 259 Patrick T. O’Gara, Joseph Loscalzo 24 Mitral Valve Disease. 274 Patrick T. O’Gara, Joseph Loscalzo 25 Tricuspid and Pulmonic Valve Disease. 286 Patrick T. O’Gara, Joseph Loscalzo 26 Multiple and Mixed Valvular Heart Disease. 292 Patrick T. O’Gara, Joseph Loscalzo 27 Cardiomyopathy and Myocarditis. 296 Neal K. Lakdawala, Lynne Warner Stevenson, Joseph Loscalzo 28 Pericardial Disease. 323 Eugene Braunwald 29 Tumors and Trauma of the Heart . 333 Eric H. Awtry, Wilson S. Colucci 30 Cardiac Manifestations of Systemic Disease. 338 Eric H. Awtry, Wilson S. Colucci 31 Infective Endocarditis . 343 Adolf W. Karchmer 32 Acute Rheumatic Fever . 359 Jonathan R. Carapetis 33 Chagas Disease and African Trypanosomiasis. 367 Louis V. Kirchhoff, Anis Rassi, Jr. 34 Cardiogenic Shock and Pulmonary Edema . 374 Judith S. Hochman, David H. Ingbar 35 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death. 382 Robert J. Myerburg, Agustin Castellanos SECTION V DISORDERS OF THE VASCULATURE 36 The Pathogenesis, Prevention, and Treatment of Atherosclerosis. 394 Peter Libby 37 Disorders of Lipoprotein Metabolism. 409 Daniel J. Rader Helen H. Hobbs 38 The Metabolic Syndrome. 431 Robert H. Eckel 39 Ischemic Heart Disease . 439 Elliott M. Antman, Joseph Loscalzo 40 Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina). 461 Christopher P. Cannon, Eugene Braunwald 41 ST-Segment Elevation Myocardial Infarction. 469 Elliott M. Antman, Joseph Loscalzo 42 Percutaneous Coronary Interventions and Other Interventional Procedures . 488 David P. Faxon, Deepak L. Bhatt 43 Hypertensive Vascular Disease. 497 Theodore A. Kotchen 44 Renovascular Disease. 521 Stephen C. Textor 45 Deep Venous Thrombosis and Pulmonary Thromboembolism. . . . . . . . . . . . . . .527 Samuel Z. Goldhaber 46 Diseases of the Aorta . 537 Mark A. Creager, Joseph Loscalzo 47 Arterial Diseases of the Extremities. 546 A. Creager Mark, Loscalzo Joseph 48 Chronic Venous Disease and Lymphedema. 557 Mark A. Creager, Joseph Loscalzo 49 Pulmonary Hypertension . 565 Aaron B. Waxman, Joseph Loscalzo SECTION VI CARDIOVASCULAR ATLASES 50 Atlas of Electrocardiography. 575 Ary L. Goldberger 51 Atlas of Noninvasive Imaging. 593 Marcelo F. Di Carli, Raymond Y. Kwong, Scott D. Solomon 52 Atlas of Cardiac Arrhythmias. 605 Ary L. Goldberger 53 Atlas of Percutaneous Revascularization. 618 Jane A. Leopold, Deepak L. Bhatt, David P. Faxon Appendix. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .631 Laboratory Values of Clinical Importance. 631 Alexander Kratz, Michael A. Pesce, Robert C. Basner, Andrew J. Einstein Review and Self-Assessment. 653 Charles M. Wiener, Cynthia D. Brown, Brian Houston Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .725