Ŀ � Chapte 1 Study on Polyphenoals in Jindai - soy ean ( Glycine max. L. Me.'Jindai') 1 1.1 Soy ean 1 1.2 Edamame 3 1.3 Polyphenols 3 1.4 Flavonoids 4 1.5 Biological Activities of the Flavonoids 4 1.6 Aim of the Pesent Study 6 Refeences 6 Chapte 2 Isolation and Chaacteization of the Polyphenols of Jindai Soy ean Leaves 10 2.1 Intoduction 10 2.2 Mateial and Methods 10 2.3 Results and Discussion 11 2.4 Conclusion 26 Refeences 26 Chapte 3 Peventive Effects of Dietay Polyphenolics of Jindai-soy ean Leaves on KK-Ay Mice 27 3.1 Intoduction 27 3.2 Mateials and Methods 27 3.3 Results 30 3.4 Discussion 35 3.5 Summay 39 Refeences 40 Chapte 4 The Anti-o esity and Anti-dia etic Effects of Kaempfeol Glycosides fom Unipe Soy ean Leaves in High-fat-diet Mice 42 4.1 Intoduction 42 4.2 Mateials and Methods 43 4.3 Results 47 4.4 Discussion 51 4.5 Conclusion 54 Refeences 54 Chapte 5 Anti -o ese and Anti -dia etic Effects of a Mixtue of Daidzin and Glycitin in C57BL/ 6J Mice Fed with a High Fat Diet 57 5.1 Intoduction 57 5.2 Mateials and Methods 58 5.3 Results 61 5.4 Discussion 65 5.5 Conclusion 68 Refeences 68 Chapte 6 Anti -dia etic Effects of Luteolin and Luteolin - 7 -O -glucoside on KK-Ay Mice 72 6.1 Intoduction 72 6.2 Mateial and Methods 72 6.3 Results 76 6.4 Discussion 80 Refeences 82 Chapte 7 Anti -o ese and Anti -dia etic Effects of Soy Glycitin on High -fat Diet-induced O ese C57BL/ 6J Mice 85 7.1 Intoduction 85 7.2 Mateials and Methods 86 7.3 Results 90 7.4 Discussion 94 7.5 Conclusion 97 Refeences 98 Chapte 8 Potective Effects of Dietay Kaempfeol Glycoside Components fom Unipe Soy ean ( Edamame, Glycine max L. Meill. ' Jindai ') Leaves and Thei Seous Meta olite on Ca on Tetachloide-induced Live Injuy Mice 101 8.1 Intoduction 101 8.2 Mateials and Methods 102 8.3 Results and Discussion 105 Refeences 111 Chapte 9 Antioxidant and Hepatopotective Activity of Kaempfeol 3-O-��-d- (2,6-di-O-��-l-hamnopyanosyl)Galactopyonoside Against Ca on Tetachloide-induced Live Injuy in Mice 114 9.1 Intoduction 114 9.2 Mateials and Methods 115 9.3 Results and Discussion 117 Refeences 121 Chapte 10 Hepatopotective Activities of Kaempfeol Glycosides Faction in Dia etic and O ese Mice 123 10.1 Intoduction 123 10.2 Mateials and Methods 124 10.3 Results 127 10.4 Discussion 129 Refeences 131 Chapte 11 Glycitein Induces ROS-dependent Apoptosis and G0 / G1 Cell Cycle Aest Though the MAPK / STAT3 / NF - ��B Pathway in Human Gastic Cance Cells 135 11.1 Intoduction 135 11.2 Mateials and Methods 136 11.3 Results 139 11.4 Discussion 149 11.5 Conclusion 152 Refeences 152 Chapte 12 Molecula Mechanisms of Quinalizain Induces Apoptosis and G0 /G1 Cell Cycle of Human Esophageal Cance HCE-4 Cells Depends on MAPK, STAT3 and NF-��B Signaling Pathways 155 12.1 Intoduction 155 12.2 Mateials and Methods 156 12.3 Results 158 12.4 Discussion 168 12.5 Conclusions 169 Refeences 170 Chapte 13 Daidzein Induces A549 Human Lung Cance Cell Apoptosis and G0 /G1 Cell Cycle Aest y Activating ROS-mediated MAPK, STAT3 and NF-��B Signaling Pathways 174 13.1 Intoduction 174 13.2 Mateials and Methods 175 13.3 Results 178 13.4 Discussion 190 13.5 Conclusions 191 Refeences 192 Chapte 14 Quinalizain Induces ROS - mediated Apoptosis Via the MAPK,STAT3, and NF-��B Signaling Pathways in Human Beast Cance Cells 196 14.1 Intoduction 196 14.2 Expeimental Section 197 14.3 Results 200 14.4 Discussion 210 Refeences 213 Chapte 15 Phenolic Contents and Compositions in Skins of Red Wine Gape Cultivas among Vaious Genetic Backgounds and Oiginations 217 15.1 Intoduction 217 15.2 Mateials and Methods 219 15.3 Results and Discussion 221 15.4 Conclusions 239 Refeences 240 Chapte 16 The Gowing Season Impacts the Accumulation and Composition of Flavonoids in Gape Skins in Two-cop-a-yea Viticultue242 16.1 Intoduction 242 16.2 Mateials and Methods 243 16.3 Results 246 16.4 Discussion and Conclusions 258 Refeences 262 Chapte 17 Effects of Exogenous A scisic Acid on Phenolic Chaacteistics of Red Vitis Vinifea Gapes and Wines 265 17.1 Intoduction 265 17.2 Mateials and Methods 266 17.3 Results and Discussion 268 Refeences 295