INTRODUCTION Chapter 1 INTRODUCTION OF DISEASE CONCEPT OF DISEASE ETIOLOGY OF DISEASE Causes of Diseases Predisposing Factors Precipitating Factors PATHOGENESIS OF DISEASE General Rules for Pathogenesis of Diseases Fundamental Mechanisms for Diseases OUTCOME OF DISEASE Complete Recovery Incomplete Recovery Death Some Special Issues Related to Death Chapter 2 GENE ABERRATION AND DYSFUNCTION ETIOLOGY AND MECHANISMS OF GENE DYSFUNCTION Chromosome Abnormalities Chromatin Abnormalities DNA Repair Errors Gene Mutation Gene Misregulation Epigenetic Influence TYPICAL EXAMPLES OF GENE DYSFUNCTIONS Chromosomal Aberrations Mendelian Single-Gene Disorders Nonmendelian Single-Gene Disorders Polygenic and Multifactorial Disorders GENETIC COUNSELING AND GENE THERAPY Genetic Counseling and Prenatal Diagnosis Gene Therapy Chapter 3 CELLULAR DYSFUNCTION CELL SIGNAL TRANSDUCTION AND DISEASE Extracellular Signal Trans-membrane Outside-in Transduction Pathways of Intracellular Signaling and Cascade Cell Response and Cell Signaling Regulation Abnormal Cell Signaling and Diseases CELL DEATH Apoptosis Autophagy Other Types of Cell Death Chapter 4 FLUID AND ELECTROLYTE HOMEOSTASIS AND IMBALANCES BODY FLUID HOMEOSTASIS Fluid Intake and Absorption Fluid Distribution Fluid Excretion and Fluid Loss Through Abnormal Routes ���� Chapter 5 ACID-BASE HOMEOSTASIS AND IMBALANCE Chapter 6 GLUCOSE METABOLIC DISTURBANCE Chapter 7 LIPID METABOLISM DISOEDERS Chapter 8 FEVER Chapter 9 STRESS Chapter 10 INFLAMMATION Chapter 11 HYPOXIA Chapter 12 ISCHEMIA-REPERFUSION INJURY Chapter 13 BLOOD COAGULATION AND ANTI-COAGULATION IMBALANCE Chapter 14 SHOCK Chapter 15 CARDIAC DYSFUNCTION Chapter 16 PULMONARY DYSFUNCTION Chapter 17 HEPATIC DYSFUNCTION Chapter 18 RENAL DYSFUNCTION Chapter 19 BRAIN DYSFUNCTION Chapter 20 MULTIPLE ORGAN DYSFUNCTION SYNDROME INDEX